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January 1, 1968Journal of Clinical InvestigationOpen Access

The effect of steady-state increases in systemic arterial pressure on the duration of left ventricular ejection time

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Why the study?

Does an increase in systemic arterial pressure prolong left ventricular ejection time in normal male subjects?

Population

11 normal male subjects

Design

Other

Authors

JSJames A. ShaverUniversity of PittsburghFKFrank W. KroetzUniversity of IowaJLJames J. LeonardGeorgetown University

Discussion

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Implication

May warrant BP adjustment in ejection time interpretation; leaves open clinical translation beyond physiologic determinants.

Structured PICO

Does an increase in systemic arterial pressure prolong left ventricular ejection time in normal male subjects?

P
Population
11 normal male subjects
I
Intervention
Intravenous methoxamine infusion to increase mean arterial pressure, with heart rate held constant by high right atrial pacing
O
Outcome
Duration of left ventricular ejection timesurrogate

Steady-state increases in systemic arterial pressure prolong left ventricular ejection time, demonstrating that arterial pressure is a prime determinant of ejection time independent of stroke volume, heart rate, and inotropic state.

Cite This Study

Shaver et al. (1968) studied this question.

synapsesocial.com/papers/6a1d3047ba65f5ee325df705https://doi.org/10.1172/jci105711
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Also Consider

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  1. 1DEPRESSION OF VENTRICULAR CONTRACTILITY BY STIMULATION OF THE VAGUS NERVES1966 · 10 citations
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  3. 3The Direct Effects of Norepinephrine, Epinephrine, and Methoxamine on Myocardial Contractile Force in Man1960 · 114 citations
  4. 4Studies on Cardiac Dimensions in Intact, Unanesthetized Man1964 · 45 citations
  5. 5Regulation of Ventricular Contraction by the Carotid Sinus1960 · 122 citations