A resting heart rate ≥83 bpm was associated with a significantly higher risk of total mortality (HR 1.32; 95% CI 1.19-1.47; P<0.0001) compared to ≤62 bpm in patients with coronary artery disease.
Cohort (n=24,913)
Effect estimate: HR 1.32 (95% CI 1.19-1.47)
p-value: p=<0.0001
AIMS: Heart rate reduction is the cornerstone of the treatment of angina. The purpose of this study was to explore the prognostic value of heart rate in patients with stable coronary artery disease (CAD). METHODS AND RESULTS: We assessed the relationship between resting heart rate at baseline and cardiovascular mortality/morbidity, while adjusting for risk factors. A total of 24 913 patients with suspected or proven CAD from the Coronary Artery Surgery Study registry were studied for a median follow-up of 14.7 years. All-cause and cardiovascular mortality and cardiovascular rehospitalizations were increased with increasing heart rate (P or =83 bpm at baseline had a significantly higher risk for total mortality [hazard ratio (HR)=1.32, CI 1.19-1.47, P or =83 bpm with patients with a heart rate < or =62 bpm, the HR values for time to first cardiovascular rehospitalization were 1.11 and 1.14, respectively (P<0.001 for both). CONCLUSION: Resting heart rate is a simple measurement with prognostic implications. High resting heart rate is a predictor for total and cardiovascular mortality independent of other risk factors in patients with CAD.
Díaz et al. (Thu,) conducted a cohort in suspected or proven coronary artery disease (n=24,913). Resting heart rate ≥83 bpm vs. Resting heart rate ≤62 bpm was evaluated on total mortality (HR 1.32, 95% CI 1.19-1.47, p=<0.0001). A resting heart rate ≥83 bpm was associated with a significantly higher risk of total mortality (HR 1.32; 95% CI 1.19-1.47; P<0.0001) compared to ≤62 bpm in patients with coronary artery disease.
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