Long-term prognostic value of resting heart rate in patients with suspected or proven coronary artery disease
Key result
A resting heart rate ≥83 bpm was associated with a significantly higher risk of total mortality (HR 1.32; 95% CI 1.19-1.47; P<0.0001) compared to ≤62 bpm in patients with coronary artery disease.
Why the study?
Does a higher resting heart rate predict increased mortality and cardiovascular rehospitalization in patients with suspected or proven CAD?
Population
24,913 patients with suspected or proven stable coronary artery disease from the Coronary Artery Surgery…
Comparison
High resting heart rate at baseline (≥83 bpm) vs Low resting heart rate at baseline (≤62 bpm)
Design
Cohort
Follow-up
median 14.7 years
Authors
Discussion
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Implication
Supports resting heart rate as a prognostic marker in stable CAD; leaves open whether lowering it improves outcomes.
Key Points
- This study investigates the prognostic significance of resting heart rate in patients with stable coronary artery disease (CAD).
- Analyzed data from 24,913 patients with suspected or proven CAD from the Coronary Artery Surgery Study registry.
- Evaluated the relationship between resting heart rate and cardiovascular mortality/morbidity.
- Median follow-up of 14.7 years, adjusting for various risk factors.
- Resting heart rate > or =83 bpm significantly associated with total mortality (HR=1.32, CI 1.19-1.47, P<0.0001) and cardiovascular mortality (HR=1.31, CI 1.15-1.48, P<0.0001).
- Higher resting heart rates correlated with increased cardiovascular rehospitalizations, with HR values of 1.11 and 1.14 for specified heart rate ranges (P<0.001).
- Increasing heart rates were linked to a rise in all-cause and cardiovascular mortality (P<0.0001).
Study Design
Type
Cohort (n=24,913)
Structured PICO
Does a higher resting heart rate predict increased mortality and cardiovascular rehospitalization in patients with suspected or proven CAD?
P
Population
24,913 patients with suspected or proven stable coronary artery disease (CAD) from the Coronary Artery Surgery Study registry
I
Intervention
High resting heart rate at baseline (≥83 bpm)
C
Comparator
Low resting heart rate at baseline (≤62 bpm)
O
Outcome
All-cause mortality, cardiovascular mortality, and cardiovascular rehospitalizations at median 14.7 years follow-uphard clinical
Main Result
Effect estimate: HR 1.32 (95% CI 1.19-1.47)
p-value: p=<0.0001
A high resting heart rate (≥83 bpm) is an independent predictor of long-term all-cause and cardiovascular mortality in patients with stable coronary artery disease.
Cite This Study
Díaz et al. (2005) conducted a cohort in suspected or proven coronary artery disease (n=24,913). Resting heart rate ≥83 bpm vs. Resting heart rate ≤62 bpm was evaluated on total mortality (HR 1.32, 95% CI 1.19-1.47, p=<0.0001). A resting heart rate ≥83 bpm was associated with a significantly higher risk of total mortality (HR 1.32; 95% CI 1.19-1.47; P<0.0001) compared to ≤62 bpm in patients with coronary artery disease.