Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

Key Points

• The aim is to investigate the protective effects of caffeine on the developing retina during ischemic conditions.
• Acute caffeine treatment was administered during induced ischemic events.
• Cell death was assessed in the developing retina after treatment.
• Mechanistic studies focused on receptor antagonism and glutamate excitotoxicity.
• Caffeine significantly reduced cell death in the developing retina during ischemia.
• Inhibition of glutamate excitotoxicity was identified as a key protective mechanism.
• Potential neuroprotective effects of caffeine suggest it could be useful in acute neurological episodes.