Identification of vulnerable ribbon synapses in aged C57BL/6 mouse cochlea

Key Points

• This research aims to identify vulnerable ribbon synapses in the cochlea of aged C57BL/6 mice to understand age-related auditory decline.
• Analyzed cochlear tissue from aged C57BL/6 mice using immunohistochemistry.
• Evaluated the integrity and functionality of ribbon synapses.
• Performed statistical analysis to identify significant differences in synaptic vulnerability.
• Significant loss of ribbon synapses was observed in aged mice compared to younger controls (P<0.01).
• Impairments in auditory signal transmission correlated with synaptic loss.
• Identified specific synaptic targets for potential therapeutic interventions.