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May 14, 2026Clinical and Experimental OtorhinolaryngologyOpen Access

Identification of vulnerable ribbon synapses in aged C57BL/6 mouse cochlea

Kwon-Woo Kang Hojin Lee Jaekwang Lee Eunyoung Yi

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Key Points

This research aims to identify vulnerable ribbon synapses in the cochlea of aged C57BL/6 mice to understand age-related auditory decline.
Analyzed cochlear tissue from aged C57BL/6 mice using immunohistochemistry.
Evaluated the integrity and functionality of ribbon synapses.
Performed statistical analysis to identify significant differences in synaptic vulnerability.
Significant loss of ribbon synapses was observed in aged mice compared to younger controls (P<0.01).
Impairments in auditory signal transmission correlated with synaptic loss.
Identified specific synaptic targets for potential therapeutic interventions.

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Implication

Identifies synaptic vulnerabilities in cochlea of aged C57BL/6 mice, highlighting implications for hearing loss.

Abstract

Age-related

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Cite This Study

Kang et al. (2026) studied this question.

synapsesocial.com/papers/6a080a29a487c87a6a40c015 https://doi.org/10.21053/ceo.2026-00037

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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