Enantioselective Total Synthesis of Verrucosamide

Key Points

• The aim is to achieve the total synthesis of verrucosamide starting from natural amino acids and establish its absolute configuration.
• Developed a 27-step total synthesis approach using a methylated 1,4-thiazepane scaffold.
• Utilized natural amino acids as starting materials.
• Addressed gaps in the synthesis of nonribosomal peptide bis-intercalators.
• Successfully established the absolute configuration of verrucosamide.
• Filled a significant void in the total synthesis of bis-intercalators.