Direct-acting oral anticoagulants were prescribed at an inappropriate dose in over 20% of older patients with atrial fibrillation, with most being underdosed.
Cohort
What is the rate of potentially inappropriate dosing of DOACs among older patients with atrial fibrillation?
Over 20% of older patients with atrial fibrillation on DOACs receive inappropriate doses, predominantly underdosing, which is not associated with geriatric conditions but may be driven by perceived bleeding risk or renal failure.
<0.05). Geriatric conditions were not associated with inappropriate dosing. Conclusions In this cohort, over 20% of older patients with atrial fibrillation treated with DOACs were prescribed an inappropriate dose, with most being underdosed. Drug-drug interactions were common. Factors that influence prescription of guideline-nonadherent doses may be perception of higher bleeding risk or presence of renal failure in addition to lack of familiarity with dosing guidelines.
Sanghai et al. (Mon,) conducted a cohort in atrial fibrillation. Direct-Acting Oral Anticoagulants (DOACs) was evaluated on Inappropriate dosing. Direct-acting oral anticoagulants were prescribed at an inappropriate dose in over 20% of older patients with atrial fibrillation, with most being underdosed.