Key result
Inappropriate DOAC dosing affects ~20% of older AF patients, mostly due to underdosing.
Why the study?
What is the rate of potentially inappropriate dosing of DOACs among older patients with atrial fibrillation?
Cohort
What is the rate of potentially inappropriate dosing of DOACs among older patients with atrial fibrillation?
Over 20% of older patients with atrial fibrillation on DOACs receive inappropriate doses, predominantly underdosing, which is not associated with geriatric conditions but may be driven by perceived bleeding risk or renal failure.
May warrant dosing review in older AF patients on DOACs; leaves open impact on outcomes.
<0.05). Geriatric conditions were not associated with inappropriate dosing. Conclusions In this cohort, over 20% of older patients with atrial fibrillation treated with DOACs were prescribed an inappropriate dose, with most being underdosed. Drug-drug interactions were common. Factors that influence prescription of guideline-nonadherent doses may be perception of higher bleeding risk or presence of renal failure in addition to lack of familiarity with dosing guidelines.
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Sanghai et al. (2020) conducted a cohort in atrial fibrillation. Direct-Acting Oral Anticoagulants (DOACs) was evaluated on Inappropriate dosing. Direct-acting oral anticoagulants were prescribed at an inappropriate dose in over 20% of older patients with atrial fibrillation, with most being underdosed.
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