This review explores the mechanisms and pathogenesis of obesity-related heart failure and the obesity paradox to guide future therapeutic approaches.
Obesity is a significant global health concern; the prevalence continues to rise in developing and developed countries. According to World Health Organization (WHO) data, 39% of the world population over the age of 18 is overweight, including 13% being obese. Numerous studies have identified an association between obesity and cardiovascular diseases (CVD), including heart failure (HF). Obesity is additionally related to an increase in the occurrence of cardiovascular (CV) disorders, including hypertension (HTN), diabetes mellitus (DM), dyslipidemias, and sleep apnea syndrome. This review investigates the various mechanisms and pathogenesis of obesity-related HF and the obesity paradox phenomena, aiming to shed light on futuristic directive approaches in treating HF-related obesity.
Husain et al. (2023) conducted a review in Obesity and Heart Failure. This review explores the mechanisms and pathogenesis of obesity-related heart failure and the obesity paradox to guide future therapeutic approaches.