Key result
Review details mechanisms of obesity-related HF and the obesity paradox to guide future therapies.
Why the study?
Obesity is a growing global health concern strongly associated with cardiovascular diseases including heart failure, warranting an investigation into the mechanisms of obesity-related heart failure, the obesity paradox, and potential future treatment approaches.
This review explores the mechanisms of obesity-related heart failure and the obesity paradox to guide future therapeutic approaches.
Does not support practice changes in obesity-HF; leaves open targeted trials on mechanisms and paradox.
Obesity is a significant global health concern; the prevalence continues to rise in developing and developed countries. According to World Health Organization (WHO) data, 39% of the world population over the age of 18 is overweight, including 13% being obese. Numerous studies have identified an association between obesity and cardiovascular diseases (CVD), including heart failure (HF). Obesity is additionally related to an increase in the occurrence of cardiovascular (CV) disorders, including hypertension (HTN), diabetes mellitus (DM), dyslipidemias, and sleep apnea syndrome. This review investigates the various mechanisms and pathogenesis of obesity-related HF and the obesity paradox phenomena, aiming to shed light on futuristic directive approaches in treating HF-related obesity.
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Husain et al. (2023) conducted a review in Obesity and Heart Failure. This review explores the mechanisms and pathogenesis of obesity-related heart failure and the obesity paradox to guide future therapeutic approaches.
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