May 14, 2025Basic Research in Cardiology12 citationsOpen Access
Effects of SGLT2 inhibitors on ion channels in heart failure: focus on the endothelium
Key Result
SGLT2 inhibitors influence endothelial ion channels, specifically NHE1 and NCX, and regulate vascular tone in heart failure.
Structured PICO
I
Intervention
SGLT2 inhibitors
This review highlights that the cardioprotective effects of SGLT2 inhibitors in heart failure may be mediated by endothelial protection via modulation of ion channels like NHE1 and NCX, leading to improved NO bioavailability and reduced oxidative stress.
Main Result
Absolute Event Rate: 0% vs 0%
Abstract
-related ion channels in endothelial cells in HF, focusing on the effects of SGLT2i on endothelial NHE1, NCX as well as on vascular tone.