SGLT2 inhibitors influence endothelial ion channels, specifically NHE1 and NCX, and regulate vascular tone in heart failure.
This review highlights that the cardioprotective effects of SGLT2 inhibitors in heart failure may be mediated by endothelial protection via modulation of ion channels like NHE1 and NCX, leading to improved NO bioavailability and reduced oxidative stress.
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-related ion channels in endothelial cells in HF, focusing on the effects of SGLT2i on endothelial NHE1, NCX as well as on vascular tone.
Wang et al. (Wed,) reported a other. SGLT2 inhibitors influence endothelial ion channels, specifically NHE1 and NCX, and regulate vascular tone in heart failure.