November 25, 1983

Elevated Skeletal Muscle Creatine Kinase MB Isoenzyme Levels in Marathon Runners

Structured PICO

Does marathon running increase the proportion of CK-MB in skeletal muscle, explaining elevated serum CK-MB after competition?

Population

108 trained marathon runners (serum analysis) and 25 trained male marathon runners with 10 sedentary male controls (skeletal muscle biopsy)

Comparator

10 sedentary male subjects (for skeletal muscle biopsy comparison)

Outcome

Creatine kinase MB isoenzyme (CK-MB) activity in serum and skeletal musclesurrogate

Elevated serum CK-MB in asymptomatic marathon runners likely originates from skeletal muscle rather than myocardium, as endurance training increases the CK-MB fraction in skeletal muscle.

Abstract

Mean serum creatine kinase MB isoenzyme (CK-MB) activity in 108 trained marathon runners after competition was 98 ±66 (SD) units/L measured by a quantitative electrophoretic technique (normal, JAMA1983;250:2835-2837)

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Cite This Study

Arthur J. Siegel (Fri,) studied this question.

synapsesocial.com/papers/6a0908a1a2bc65e38873bdf8 https://doi.org/https://doi.org/10.1001/jama.1983.03340200069032

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