Why the study?
Does marathon running increase the proportion of CK-MB in skeletal muscle, explaining elevated serum CK-MB after competition?
Population
108 trained marathon runners and 25 trained male marathon runners with 10 sedentary male controls
Design
Cross-sectional
Authors
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Caution against misinterpreting post-marathon CK-MB as cardiac; supports training-associated skeletal isoform shift but leaves confirmation to prospective studies.
Does marathon running increase the proportion of CK-MB in skeletal muscle, explaining elevated serum CK-MB after competition?
Elevated serum CK-MB in asymptomatic marathon runners likely originates from skeletal muscle rather than myocardium, as endurance training increases the CK-MB fraction in skeletal muscle.
Arthur J. Siegel (1983) studied this question.
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