November 6, 1981JAMA

Elevated creatine kinase MB isoenzyme levels in marathon runners. Normal myocardial scintigrams suggest noncardiac source

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Why the study?

Does marathon running cause elevated CK-MB levels of cardiac origin in male runners?

Population

35 male marathon runners

Design

Cohort, 12 randomly selected runners for scintigraphy

Follow-up

24 hours after competition

Authors

ASArthur J. SiegelHarvard University

Discussion

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Implication

May not indicate myocardial injury in asymptomatic runners; supports skeletal origin but leaves open prospective validation.

Structured PICO

Does marathon running cause elevated CK-MB levels of cardiac origin in male runners?

Population

35 male marathon runners

Intervention

Marathon running (training and competition)

Outcome

Serum CK-MB levels and myocardial scintigraphy with technetium Tc 99m pyrophosphatesurrogate

Marked elevation of CK-MB in marathon runners is likely derived from skeletal muscle rather than myocardial injury, as confirmed by normal myocardial scintigraphy.

Cite This Study

Arthur J. Siegel (1981) studied this question.

synapsesocial.com/papers/6a9858f1f8d38b172f40e615 https://doi.org/10.1001/jama.246.18.2049

View Full Paper

Ask AI

Bookmark

Elevated creatine kinase MB isoenzyme levels in marathon runners. Normal myocardial scintigrams suggest noncardiac source

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Elevated creatine kinase MB isoenzyme levels in marathon runners. Normal myocardial scintigrams suggest noncardiac source

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider