Fasting plasma glucose correlated inversely with left ventricular diastolic function (Em/Am ratio, r=-0.53, P=0.001) in middle-aged individuals without diagnosed diabetes.
Cross-Sectional (n=35)
No
Glucose concentrations in the upper normal range are associated with impaired left ventricular diastolic function in middle-aged individuals without diabetes.
Effect estimate: r=-0.53
p-value: p=0.001
OBJECTIVES: To examine the relation between left ventricular (LV) diastolic function and glucose metabolism in individuals without previously diagnosed diabetes mellitus. DESIGN: A cross-sectional population-based study. SETTING: A university hospital. SUBJECTS: Thirty-five men and women 56-58 years of age without previously diagnosed diabetes or heart disease. MAIN OUTCOME MEASURES: Left ventricular diastolic function assessed by pulsed Doppler tissue imaging and its relation to fasting plasma glucose, glucose postload and glycated haemoglobin. LV diastolic function was determined by measuring early diastolic filling peak velocity (Em wave cm s-1), late diastolic filling peak velocity (Am wave cm s-1) and their ratio Em/Am. RESULTS: Peak Em velocity, peak Am velocity and their ratio Em/Am correlated with fasting plasma glucose (r=-0.42, P=0.01; r=0.47, P=0.04 and r=-0.53, P=0.001, respectively). There was a correlation between peak Em velocity, the ratio of Em/Am and glycated haemoglobin. LV diastolic function was also related to glucose postload. CONCLUSIONS: Left ventricular diastolic function is related to concentrations of fasting plasma glucose, glucose postload and glycated haemoglobin even below the threshold of diabetes. This indicates that glucose concentrations already in the upper end of the normal range has negative impact on cardiac function.
Holzmann et al. (Tue,) conducted a cross-sectional in Without previously diagnosed diabetes mellitus or heart disease (n=35). Glucose metabolism markers (fasting plasma glucose, glucose postload, glycated haemoglobin) was evaluated on Left ventricular diastolic function (Em, Am, Em/Am ratio) (r=-0.53, p=0.001). Fasting plasma glucose correlated inversely with left ventricular diastolic function (Em/Am ratio, r=-0.53, P=0.001) in middle-aged individuals without diagnosed diabetes.