Left ventricular diastolic function is related to glucose in a middle‐aged population
Key result
Fasting plasma glucose correlated inversely with left ventricular diastolic function (Em/Am ratio, r=-0.53, P=0.001) in middle-aged individuals without diagnosed diabetes.
Population
35 men and women 56-58 years of age without previously diagnosed diabetes or heart disease.
Design
Cross-sectional
Authors
Discussion
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Implication
May support diastolic screening in higher-normal glucose; leaves open causal role and intervention trials in nondiabetics.
Study Design
Type
Cross-Sectional (n=35)
Multicenter
No
Structured PICO
P
Population
35 men and women 56-58 years of age without previously diagnosed diabetes or heart disease.
O
Outcome
Left ventricular diastolic function assessed by pulsed Doppler tissue imaging (early diastolic filling peak velocity [Em], late diastolic filling peak velocity [Am], and Em/Am ratio) and its relation to fasting plasma glucose, glucose postload and glycated haemoglobin.surrogate
Main Result
Effect estimate: r=-0.53
p-value: p=0.001
Glucose concentrations in the upper normal range are associated with impaired left ventricular diastolic function in middle-aged individuals without diabetes.
Cite This Study
Holzmann et al. (2002) conducted a cross-sectional in Without previously diagnosed diabetes mellitus or heart disease (n=35). Glucose metabolism markers (fasting plasma glucose, glucose postload, glycated haemoglobin) was evaluated on Left ventricular diastolic function (Em, Am, Em/Am ratio) (r=-0.53, p=0.001). Fasting plasma glucose correlated inversely with left ventricular diastolic function (Em/Am ratio, r=-0.53, P=0.001) in middle-aged individuals without diagnosed diabetes.