Trandolapril treatment for 3 months significantly reduced cardiac hypertrophy, fibrosis, and the incidence of ventricular premature beats in middle-aged spontaneously hypertensive rats.
Does trandolapril reduce ventricular ectopic activity, hypertrophy, and fibrosis in middle-aged spontaneously hypertensive rats?
Trandolapril reduces ventricular premature beats, cardiac hypertrophy, and fibrosis in a rat model of hypertensive heart disease.
BACKGROUND: Although severe arrhythmias are still a major problem in patients with left ventricular hypertrophy (LVH), the relationship between ventricular remodeling and its regression or prevention, and the prevalence of ventricular premature beats (VPB) or more sustained arrhythmias are still poorly explored in hypertensive heart disease. METHODS AND RESULTS: Holter monitoring was used to quantify supraventricular premature beats and VPB and heart rate (HR) in middle-aged spontaneously hypertensive rats (SHR) and Wistar rats treated for 3 months with trandolapril (ACE inhibitor, 0.3 mg/kg per day). Hypertrophy and fibrosis were morphometrically determined. Statistical analysis was performed with the use of simple regression and multivariate data analysis (cluster and correspondence analysis). SHR have higher cardiac mass and fibrosis, more VPB, and a decreased HR. Cluster analysis demonstrated that trandolapril was only effective in SHR. Trandolapril significantly reduced cardiac hypertrophy, fibrosis, and VPB incidence and increased the HR. Simple regression analysis showed that VPB incidence correlated to both hypertrophy and fibrosis. Correspondence analysis evidenced a strong correlation between hypertrophy, fibrosis, and VPB, but only for severe hypertrophy, and the correlation disappeared for moderate hypertrophy. CONCLUSIONS: After trandolapril treatment, the regression of VPB incidence not only is linked to hypertrophy and fibrosis, but additional causal factors also are involved including the myocardial phenotype and new calcium metabolism. Our model of Holter monitoring in conscious middle-aged SHR and multivariate data analysis might be useful in correlating myocardial structural modifications and ectopic activity.
Chevalier et al. (Sun,) conducted a other in Left ventricular hypertrophy and arrhythmias. Trandolapril vs. Untreated SHR / Wistar rats was evaluated on Incidence of ventricular premature beats (VPB), cardiac hypertrophy, and fibrosis. Trandolapril treatment for 3 months significantly reduced cardiac hypertrophy, fibrosis, and the incidence of ventricular premature beats in middle-aged spontaneously hypertensive rats.