Key result
Trandolapril treatment for 3 months significantly reduced cardiac hypertrophy, fibrosis, and the incidence of ventricular premature beats in middle-aged spontaneously hypertensive rats.
Why the study?
Does trandolapril reduce ventricular ectopic activity, hypertrophy, and fibrosis in middle-aged spontaneously hypertensive rats?
Population
Middle-aged spontaneously hypertensive rats (SHR) and Wistar rats
Design
Preclinical
Follow-up
3 months
Authors
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Should not change practice; hypothesis-generating for ACE inhibition in hypertensive heart disease.
Does trandolapril reduce ventricular ectopic activity, hypertrophy, and fibrosis in middle-aged spontaneously hypertensive rats?
Trandolapril reduces ventricular premature beats, cardiac hypertrophy, and fibrosis in a rat model of hypertensive heart disease.
Chevalier et al. (1995) studied Left ventricular hypertrophy and arrhythmias. Trandolapril vs. Untreated SHR / Wistar rats was evaluated on Incidence of ventricular premature beats (VPB), cardiac hypertrophy, and fibrosis. Trandolapril treatment for 3 months significantly reduced cardiac hypertrophy, fibrosis, and the incidence of ventricular premature beats in middle-aged spontaneously hypertensive rats.
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