Low-Molecular-Weight Fraction of Ripe Pu-erh Tea Protects against Alcohol-Induced Gastric Injury via Gut Microbiota-Dependent Modulation

Key Points

• The study aims to evaluate the protective effects of a low-molecular-weight fraction of ripe Pu-erh tea against alcohol-induced gastric injury (AGI).
• Evaluated the efficacy of low-molecular-weight fraction from ripe Pu-erh tea in protecting against AGI.
• Utilized antibiotics to deplete gut microbiota, assessing its role in the modulation mechanism.
• Conducted serum metabolomics analysis to investigate glutathione-related pathway regulation.
• High butyrate production was observed in the treatment group, indicating beneficial gut microbiota effects.
• Antibiotic treatment reduced the efficacy of Pu-erh tea, confirming a microbiota-dependent mechanism.
• Metabolomics revealed significant regulation of glutathione pathways due to Pu-erh tea treatment.