Low-Molecular-Weight Fraction of Ripe Pu-erh Tea Protects against Alcohol-Induced Gastric Injury via Gut Microbiota-Dependent Modulation

Sibo Zhao; Jielin Jiang; Mianhong Xu; Yan Liu; Lifeng Dai; Xingli Guan; Ruisheng Li; Lijuan Chen; Xingping Zhao; Kaiyang Lu; Li Luo; Liang Zeng

doi:10.1021/acs.jafc.6c01237

May 18, 2026Journal of Agricultural and Food Chemistry

Low-Molecular-Weight Fraction of Ripe Pu-erh Tea Protects against Alcohol-Induced Gastric Injury via Gut Microbiota-Dependent Modulation

View Full Paper

Ask AI

Bookmark

Share

Key Points

The study aims to evaluate the protective effects of a low-molecular-weight fraction of ripe Pu-erh tea against alcohol-induced gastric injury (AGI).
Evaluated the efficacy of low-molecular-weight fraction from ripe Pu-erh tea in protecting against AGI.
Utilized antibiotics to deplete gut microbiota, assessing its role in the modulation mechanism.
Conducted serum metabolomics analysis to investigate glutathione-related pathway regulation.
High butyrate production was observed in the treatment group, indicating beneficial gut microbiota effects.
Antibiotic treatment reduced the efficacy of Pu-erh tea, confirming a microbiota-dependent mechanism.
Metabolomics revealed significant regulation of glutathione pathways due to Pu-erh tea treatment.

Implication

Demonstrates protection against alcohol-induced gastric injury in a microbiota-dependent manner, suggesting dietary benefits.

Abstract

and increased butyrate production. Antibiotic-mediated microbiota depletion attenuated T3 efficacy, supporting a microbiota-dependent mechanism. Serum metabolomics further indicated regulation of glutathione-related pathways. Overall, T3 represents a promising low-molecular-weight fraction of Pu-erh tea for dietary prevention of AGI through modulation of microbiota-gut-stomach homeostasis.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Zhao et al. (2026) studied this question.

synapsesocial.com/papers/6a0ea074be05d6e3efb5f3eb https://doi.org/10.1021/acs.jafc.6c01237

View Full Paper

Ask AI

Bookmark

Share

Low-Molecular-Weight Fraction of Ripe Pu-erh Tea Protects against Alcohol-Induced Gastric Injury via Gut Microbiota-Dependent Modulation

Key Points

Implication

Abstract

Discussion

Cite This Study

Low-Molecular-Weight Fraction of Ripe Pu-erh Tea Protects against Alcohol-Induced Gastric Injury via Gut Microbiota-Dependent Modulation

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading