Sodium Borohydride: Repurposing From Reducing Agent to Reductive Cyclization Reagent for N-(2-Iodoaryl)Acrylamides

Key Points

• The study aims to explore the repurposing of sodium borohydride for reductive cyclization of N-(2-iodoaryl)acrylamides.
• Investigated the reaction of N-(2-iodoaryl)acrylamides with sodium borohydride as a cyclization reagent.
• Compared the effectiveness of various hydride donors in the cyclization process.
• Employed standard laboratory techniques to analyze the products formed.
• Sodium borohydride successfully facilitated the formation of oxindoles from N-(2-iodoaryl)acrylamides.
• Other hydride donors failed to achieve the same cyclization, highlighting sodium borohydride's unique properties.