Female gender was an independent predictor for atrial fibrillation recurrence after the first catheter ablation (HR 1.663; 95% CI 1.114-2.485; P=0.013) and had lower initial success (35.6% vs 57.1%).
Cohort (n=220)
Does female gender worsen the efficacy and safety outcomes of catheter ablation in patients with long-standing persistent atrial fibrillation?
In patients with long-standing persistent AF undergoing catheter ablation, women have lower initial success rates, higher recurrence risk, and more vascular complications compared to men.
Effect estimate: HR 1.663 (95% CI 1.114-2.485)
p-value: p=0.013
OBJECTIVES: It is uncertain whether gender affects the outcomes of catheter ablation (CA) for atrial fibrillation (AF). The objective of the study is to evaluate the efficacy and safety of CA for long-standing persistent AF in women. METHODS: Between January 2010 and May 2011, 220 consecutive patients (73 females, 33.2%), with long-standing persistent AF who underwent CA were prospectively recruited. Gender-related differences in clinical presentation, periprocedural complications, and outcomes were compared. RESULTS: Women were less likely to have lone AF than men (27.4% vs 47.6%; P = 0.004). The incidence of rheumatic heart disease was higher in women (19.2% in women vs 1.4% in men; P < 0.001). Women had a lower initial ablation success rate than men (35.6% vs 57.1%; P = 0.003). Hematomas occurred more often in women (6.8% in women vs 0.7% in men; P = 0.027). A Cox regression analysis demonstrated total duration of AF (per month, hazard ratio HR 1.003, confidence interval CI 1.001-1.006; P = 0.006) and gender (HR 1.663, CI 1.114-2.485; P = 0.013) as the independent predictors for recurrence after the first CA. CONCLUSIONS: Women and long AF duration were closely related to the recurrence of AF after the first ablation in patients with long-standing persistent AF. Women also had a higher risk of vascular complications.
ZHANG et al. (Wed,) conducted a cohort in Long-standing persistent atrial fibrillation (n=220). Female gender (undergoing catheter ablation) vs. Male gender was evaluated on Recurrence after the first catheter ablation (HR 1.663, 95% CI 1.114-2.485, p=0.013). Female gender was an independent predictor for atrial fibrillation recurrence after the first catheter ablation (HR 1.663; 95% CI 1.114-2.485; P=0.013) and had lower initial success (35.6% vs 57.1%).