Global age-standardized cardiovascular disease mortality rates significantly declined by an average of 3.82 per 100,000 individuals annually between 1990 and 2017, with developed countries experiencing faster reductions than developing nations.
Observational
Global CVD incidence and mortality rates have generally trended downward since the late 1990s, though the survival rate (MIR) has remained relatively stable, highlighting the need for improved patient survival strategies.
Effect estimate: Slope -3.82
p-value: p=<0.001
BACKGROUND: Cardiovascular diseases (CVDs) are one of the global leading causes of concern due to the rising prevalence and consequence of mortality and disability with a heavy economic burden. The objective of the current study was to analyze the trend in CVD incidence, mortality, and mortality-to-incidence ratio (MIR) across the world over 28 years. METHODS: The age-standardized CVD mortality and incidence rates were retrieved from the Global Burden of Disease (GBD) Study 2017 for both genders and different world super regions with available data every year during the period 1990-2017. Additionally, the Human Development Index was sourced from the United Nations Development Programme (UNDP) database for all countries at the same time interval. The marginal modeling approach was implemented to evaluate the mean trend of CVD incidence, mortality, and MIR for 195 countries and separately for developing and developed countries and also clarify the relationship between the indices and Human Development Index (HDI) from 1990 to 2017. RESULTS: The obtained estimates identified that the global mean trend of CVD incidence had an ascending trend until 1996 followed by a descending trend after this year. Nearly all of the countries experienced a significant declining mortality trend from 1990 to 2017. Likewise, the global mean MIR rate had a significant trivial decrement trend with a gentle slope of 0.004 over the time interval. As such, the reduction in incidence and mortality rates for developed countries was significantly faster than developing counterparts in the period 1990-2017 (p < 0.05). Nevertheless, the developing nations had a more rather shallow decrease in MIR compared to developed ones. CONCLUSIONS: Generally, the findings of this study revealed that there was an overall downward trend in CVD incidence and mortality rates, while the survival rate of CVD patients was rather stable. These results send a satisfactory message that global effort for controlling the CVD burden was quite successful. Nonetheless, there is an urgent need for more efforts to improve the survival rate of patients and lower the burden of this disease in some areas with an increasing trend of either incidence or mortality.
Amini et al. (Thu,) conducted a observational in Cardiovascular disease. Time trend analysis was evaluated on Global age-standardized CVD mortality rate trend (Slope -3.82, p=<0.001). Global age-standardized cardiovascular disease mortality rates significantly declined by an average of 3.82 per 100,000 individuals annually between 1990 and 2017, with developed countries experiencing faster reductions than developing nations.
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