Key result
Global CVD mortality falls by ~4 per 100,000 annually, with faster declines in developed nations.
Why the study?
Cardiovascular diseases are a leading global concern causing significant mortality, disability, and economic burden, prompting the need to analyze long-term global trends in CVD incidence, mortality, and mortality-to-incidence ratio.
Population
Age-standardized data for both genders from 195 countries across world super regions
Comparison
Developing vs developed countries and trends across Human Development Index levels
Design
Marginal modeling trend analysis of Global Burden of Disease Study 2017 data
Follow-up
28 years (1990-2017)
Authors
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Uneven declines underscore need for targeted prevention in developing nations; leaves open whether MIR gains can further improve survival.
Observational
Effect estimate: Slope -3.82
p-value: p=<0.001
Global CVD incidence and mortality rates have generally trended downward since the late 1990s, though the survival rate (MIR) has remained relatively stable, highlighting the need for improved patient survival strategies.
Amini et al. (2021) conducted an observational in Cardiovascular disease. Time trend analysis was evaluated on Global age-standardized CVD mortality rate trend (Slope -3.82, p=<0.001). Global age-standardized cardiovascular disease mortality rates significantly declined by an average of 3.82 per 100,000 individuals annually between 1990 and 2017, with developed countries experiencing faster reductions than developing nations.
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