Cigarettes, IQOS, and e-cigarettes similarly increased hemodynamics and arterial stiffness, but only nicotine-containing products increased bronchial obstruction and reactance.
Do e-cigarettes and heated tobacco products improve hemodynamics, arterial stiffness, and small airway function compared to conventional cigarettes in occasional smokers?
E-cigarettes and heated tobacco products have similar adverse acute effects on hemodynamics and arterial stiffness as conventional cigarettes, suggesting they are not healthier alternatives.
Introduction: E-cigarettes and heated tobacco products (HTPs) are gaining worldwide significance. The tobacco industry is promoting these products as healthier alternatives to conventional cigarettes. Methods: In this four-arm crossover study, we examined the acute effects of cigarette smoking, vaping IQOS, or vaping e-cigarettes (with or without nicotine) on hemodynamics, arterial stiffness, and small airways. Twenty subjects (10 male, 10 female), all occasional smokers, completed each study arm. There was at least a 48 h washout period before each test day. Arterial stiffness and peripheral and central hemodynamics were assessed using Mobil-O-Graph™ (I.E.M., Germany), whereas tremoFlo® c-100 (Thoracic Medical Systems Inc) was used to evaluate the effects on the small airways and resistance. Results: Cigarettes, IQOS, e-cigarettes containing nicotine, and nicotine-free e-cigarettes had similar effects on peripheral and central hemodynamics as well as on arterial stiffness. We observed a significant increase in all parameters. However, only nicotine-containing products lead to increased bronchial obstruction, higher reactance, and a higher tidal volume. Conclusion: Therefore, we concluded that cigarettes, IQOS, and e-cigarettes have similar effects on hemodynamics. No differences were observed between the nicotine-containing and nicotine-free e-cigarettes. All nicotine-containing products also influence small airways. These findings suggest that e-cigarettes and HTPs are not healthier alternatives than conventional cigarettes.
Jung et al. (Thu,) conducted a other in Occasional smokers (n=20). Cigarette smoking, vaping IQOS, or vaping e-cigarettes (with or without nicotine) vs. Crossover comparison between the four products was evaluated on Hemodynamics, arterial stiffness, and small airways. Cigarettes, IQOS, and e-cigarettes similarly increased hemodynamics and arterial stiffness, but only nicotine-containing products increased bronchial obstruction and reactance.
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