Key result
Cigarettes, IQOS, and e-cigarettes similarly increase arterial stiffness, but only nicotine products worsen bronchial obstruction.
Why the study?
E-cigarettes and heated tobacco products are gaining worldwide significance and are promoted as healthier alternatives to conventional cigarettes, requiring evaluation of their acute effects.
Do e-cigarettes and heated tobacco products improve hemodynamics, arterial stiffness, and small airway function compared to conventional cigarettes in occasional smokers?
Do e-cigarettes and heated tobacco products improve hemodynamics, arterial stiffness, and small airway function compared to conventional cigarettes in occasional smokers?
E-cigarettes and heated tobacco products have similar adverse acute effects on hemodynamics and arterial stiffness as conventional cigarettes, suggesting they are not healthier alternatives.
Similar acute effects across products warrant caution against harm-reduction assumptions; leaves open nicotine-specific airway impacts in larger trials.
Introduction: E-cigarettes and heated tobacco products (HTPs) are gaining worldwide significance. The tobacco industry is promoting these products as healthier alternatives to conventional cigarettes. Methods: In this four-arm crossover study, we examined the acute effects of cigarette smoking, vaping IQOS, or vaping e-cigarettes (with or without nicotine) on hemodynamics, arterial stiffness, and small airways. Twenty subjects (10 male, 10 female), all occasional smokers, completed each study arm. There was at least a 48 h washout period before each test day. Arterial stiffness and peripheral and central hemodynamics were assessed using Mobil-O-Graph™ (I.E.M., Germany), whereas tremoFlo® c-100 (Thoracic Medical Systems Inc) was used to evaluate the effects on the small airways and resistance. Results: Cigarettes, IQOS, e-cigarettes containing nicotine, and nicotine-free e-cigarettes had similar effects on peripheral and central hemodynamics as well as on arterial stiffness. We observed a significant increase in all parameters. However, only nicotine-containing products lead to increased bronchial obstruction, higher reactance, and a higher tidal volume. Conclusion: Therefore, we concluded that cigarettes, IQOS, and e-cigarettes have similar effects on hemodynamics. No differences were observed between the nicotine-containing and nicotine-free e-cigarettes. All nicotine-containing products also influence small airways. These findings suggest that e-cigarettes and HTPs are not healthier alternatives than conventional cigarettes.
No takes yet. Share an insight, caveat, or question.
Jung et al. (2024) studied Occasional smokers (n=20). Cigarette smoking, vaping IQOS, or vaping e-cigarettes (with or without nicotine) vs. Crossover comparison between the four products was evaluated on Hemodynamics, arterial stiffness, and small airways. Cigarettes, IQOS, and e-cigarettes similarly increased hemodynamics and arterial stiffness, but only nicotine-containing products increased bronchial obstruction and reactance.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: