In 390 male workers, glucose and insulin levels significantly correlated with relative wall thickness independent of blood pressure, suggesting they promote concentric left ventricular changes.
Cross-Sectional (n=390)
Does hyperglycemia or hyperinsulinemia influence left ventricular mass and geometry in normotensive and mildly to moderately hypertensive men?
Hyperglycemia and hyperinsulinemia are independently associated with concentric left ventricular geometric changes in men without known cardiac disease.
The present study was designed to test whether hyperglycemia or hyperinsulinemia influences left ventricular mass and geometry. An echocardiogram and 75-g oral glucose tolerance test were performed in 210 normotensive and 180 mildly to moderately hypertensive male workers in a bus company who were free from cardiac diseases and were not taking medication for hypertension and diabetes mellitus. When we divided subjects into four groups according to the left ventricular geometric pattern using left ventricular mass index of 110 g/m2 and relative wall thickness (ratio of 2 x posterior wall thickness to end-diastolic left ventricular diameter) of 0.44, body mass index and systolic blood pressure were higher in those with concentric hypertrophy and eccentric hypertrophy. In addition, hemoglobin A(Ic) level and the sum of fasting and 2-hour postload serum glucose levels were higher in subjects with concentric hypertrophy. In subjects without diabetes mellitus (n=336), 2-hour postload serum insulin level and the sum of fasting and 2-hour postload serum insulin levels tended to be higher in those with concentric hypertrophy and concentric remodeling. In multiple regression analysis, the sum of glucose levels (or hemoglobin A(Ic) level) in all subjects and the sum of insulin (or 2-hour postload insulin) levels in subjects without diabetes mellitus significantly correlated with relative wall thickness, independent of age, systolic blood pressure, and body mass index. Neither glucose nor insulin levels correlated with left ventricular mass index. Our results suggest that hyperglycemia and hyperinsulinemia may promote concentric changes in the left ventricle in normotensive and mildly to moderately hypertensive men.
Ohya et al. (Fri,) conducted a cross-sectional in Normotension and mild to moderate hypertension (n=390). Hyperglycemia and hyperinsulinemia (Exposure) was evaluated on Left ventricular mass and geometry (relative wall thickness and left ventricular mass index). In 390 male workers, glucose and insulin levels significantly correlated with relative wall thickness independent of blood pressure, suggesting they promote concentric left ventricular changes.
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