August 10, 2011
Calcium Cycling Proteins and Their Association With Heart Failure
Key Result
Defective excitation-contraction coupling in heart failure may result from altered density or function of proteins relevant for calcium homeostasis.
PICO
P
Population
Heart failure
Abstract
Heart failure (HF) has reached epidemic proportions in the United States and is one of the most important challenges to public health. Severe congestive HF is associated with substantial morbidity and mortality. HF afflicts approximately 5 million patients and contributes to 3 million hospitalizations and 300,000 deaths yearly. Late-stage HF has a poor prognosis, and therapeutic options are limited. Defective excitation–contraction (EC) coupling in HF may result from altered density or function of proteins relevant for Ca2+ homeostasis.