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Amajor factor in the rapid advance of medical scienceover the past 50 years has been the development and refinement of the clinical research method known as the randomized controlled trial (RCT). A clinical trial is defined as a prospective scientific experiment that involves human subjects in whom treatment is initiated for the evaluation of a therapeutic intervention. In an RCT, each patient is assigned to receive a specific treatment intervention by a chance mechanism. Nothing more clearly indicates the key role of an RCT in modern clinical research than the placement of this specific research method at the top of the list of levels of evidence in evidence-based medicine.1 According to this classification, significant results of an RCT are more definitive than any other type of clinical research information. The purpose of this article is to present an overview of the
Kenneth Stanley (Mon,) studied this question.
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