June 10, 1983
View Full PaperClot-Selective Coronary Thrombolysis with Tissue-Type Plasminogen Activator
Structured PICO
Does intravenous tissue-type plasminogen activator induce coronary thrombolysis in a canine model of acute myocardial infarction?
P
Population
Dogs with acute myocardial infarction model
I
Intervention
Intravenous tissue-type plasminogen activator
O
Outcome
Coronary thrombolysis (clot lysis)surrogate
Intravenous tissue-type plasminogen activator rapidly induces coronary thrombolysis and restores myocardial blood flow in a canine model without causing systemic fibrinolysis.
Abstract
Coronary thrombolysis, an intervention that can abort the sequelae of acute myocardial infarction, was accomplished within 10 minutes in dogs by intravenous administration of clot-selective, tissue-type plasminogen activator. In addition to inducing clot lysis, this promising fibrinolytic agent restored intermediary metabolism and nutritional myocardial blood flow, detectable noninvasively with positron tomography, without inducing a systemic fibrinolytic state.
Cite This Study
Bergmann et al. (Fri,) studied this question.