Does intravenous tissue-type plasminogen activator induce coronary thrombolysis in a canine model of acute myocardial infarction?
Intravenous tissue-type plasminogen activator rapidly induces coronary thrombolysis and restores myocardial blood flow in a canine model without causing systemic fibrinolysis.
Coronary thrombolysis, an intervention that can abort the sequelae of acute myocardial infarction, was accomplished within 10 minutes in dogs by intravenous administration of clot-selective, tissue-type plasminogen activator. In addition to inducing clot lysis, this promising fibrinolytic agent restored intermediary metabolism and nutritional myocardial blood flow, detectable noninvasively with positron tomography, without inducing a systemic fibrinolytic state.
Bergmann et al. (1983) studied this question.