Key result
Thrombolysin infused via the coronary artery or left ventricle, but not the femoral vein, lysed only recent (<2 hr) thrombi in dogs, while intracoronary use caused significant haemorrhage.
Why the study?
Does Thrombolysin administration route affect lysis of coronary thrombi in dogs?
Population
Dogs with a platelet coronary thrombus
Design
Preclinical
Authors
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Intracoronary Thrombolysin risks hemorrhage despite lysing early thrombi in dogs; leaves open translation to clinical coronary thrombolysis.
Does Thrombolysin administration route affect lysis of coronary thrombi in dogs?
In a canine model, Thrombolysin effectively lysed recent coronary thrombi when administered via the coronary artery or left ventricle, though intracoronary administration caused significant myocardial hemorrhage.
Moschos et al. (1970) studied this question. Thrombolysin infused via the coronary artery or left ventricle, but not the femoral vein, lysed only recent (<2 hr) thrombi in dogs, while intracoronary use caused significant haemorrhage.
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