Why the study?
Does native t-PA improve coronary recanalization compared to urokinase in a canine model of coronary thrombosis?
Population
16 dogs with experimental coronary occlusive thrombus produced by partial constriction and endothelial…
Comparison
Native tissue-type plasminogen activator 0.375… vs Urokinase 20,000 IU/kg intravenously
Design
Preclinical
Authors
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Animal data suggest t-PA fibrin specificity; leaves open translation to human thrombolysis.
Does native t-PA improve coronary recanalization compared to urokinase in a canine model of coronary thrombosis?
In a canine model of coronary thrombosis, native t-PA provided similar coronary recanalization rates to urokinase but with significantly less depletion of plasma fibrinogen.
Tomaru et al. (1989) studied this question.
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