Questions CAD-centric model of age-related HF; extends evidence for independent presbycardia effects in hypertrophy.
Key Points
Investigate the relationship of coronary artery disease severity and myocardial infarctions to the development of cardiac hypertrophy and chronic congestive heart failure in older individuals.
Evaluated pathological and clinical evidence linking coronary arteriosclerosis and prior myocardial infarctions to cardiac enlargement.
Differentiated ischemic drivers of congestive heart failure from age-associated cardiac structural alterations (presbycardia).
Assesses coronary artery disease severity as a primary determinant of cardiac hypertrophy in the absence of primary valvular or hypertensive heart disease.
Examines the extent to which coronary narrowing and infarction burden account for heart failure symptoms versus non-ischemic age-related changes.