What question did this study set out to answer?

Investigate the relationship of coronary artery disease severity and myocardial infarctions to the development of cardiac hypertrophy and chronic congestive heart failure in older individuals.

March 15, 1962New England Journal of Medicine38 citations

Relation of the Degree of Coronary-Artery Disease and of Myocardial Infarctions to Cardiac Hypertrophy and Chronic Congestive Heart Failure

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LELaurence B. Ellis RARobert Allison FRFelix L. Rodriguez

Key Points

Investigate the relationship of coronary artery disease severity and myocardial infarctions to the development of cardiac hypertrophy and chronic congestive heart failure in older individuals.
Evaluated pathological and clinical evidence linking coronary arteriosclerosis and prior myocardial infarctions to cardiac enlargement.
Differentiated ischemic drivers of congestive heart failure from age-associated cardiac structural alterations (presbycardia).
Assesses coronary artery disease severity as a primary determinant of cardiac hypertrophy in the absence of primary valvular or hypertensive heart disease.
Examines the extent to which coronary narrowing and infarction burden account for heart failure symptoms versus non-ischemic age-related changes.

Abstract

HEART disease and heart failure in aging persons are usually assumed to be due to coronary arteriosclerosis (arteriosclerotic heart disease, ischemic heart disease) if other identifiable causes of heart disease can be excluded, notably hypertensive cardiovascular disease and chronic valvular disease. From time to time this assumption is challenged, and presbycardia (or "the senile heart") is believed by some to be produced by physiologic, biochemical or even morphologic alterations associated with old age, without relation to the degree of coronary disease.Another question is concerned with the causation of cardiac hypertrophy, which is one of the objective clinical findings most . . .

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Ellis et al. (1962) studied this question.

synapsesocial.com/papers/6a1ae7854dcca2706385d695 https://doi.org/10.1056/nejm196203152661101

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March 15, 1962New England Journal of Medicine38 citations

Relation of the Degree of Coronary-Artery Disease and of Myocardial Infarctions to Cardiac Hypertrophy and Chronic Congestive Heart Failure

View Full Paper

LELaurence B. Ellis RARobert Allison FRFelix L. Rodriguez

Key Points

Investigate the relationship of coronary artery disease severity and myocardial infarctions to the development of cardiac hypertrophy and chronic congestive heart failure in older individuals.
Evaluated pathological and clinical evidence linking coronary arteriosclerosis and prior myocardial infarctions to cardiac enlargement.
Differentiated ischemic drivers of congestive heart failure from age-associated cardiac structural alterations (presbycardia).
Assesses coronary artery disease severity as a primary determinant of cardiac hypertrophy in the absence of primary valvular or hypertensive heart disease.
Examines the extent to which coronary narrowing and infarction burden account for heart failure symptoms versus non-ischemic age-related changes.

Abstract

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Cite This Study

Ellis et al. (1962) studied this question.

synapsesocial.com/papers/6a1ae7854dcca2706385d695 https://doi.org/10.1056/nejm196203152661101

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View Full Paper