Leisure time physical activity in the highest tertile reduced the risk of myocardial infarction by 21% compared to the lowest tertile among all participants.
Cohort (n=31,580)
Yes
Does higher total and leisure time physical activity reduce the risk of myocardial infarction and stroke in adults without prior cardiovascular disease?
Higher leisure time physical activity in men and higher total physical activity in women are associated with a significantly reduced risk of incident myocardial infarction.
Effect estimate: HR 0.79 (95% CI 0.66-0.94)
p-value: p=<0.01
BACKGROUND: Physical inactivity is a known risk factor for cardiovascular disease, but it is unclear if total and leisure time activity have different impact on the risk of myocardial infarction and stroke. In this cohort, we aimed to investigate the associations between both total and leisure time physical activity in detail, and the risks of myocardial infarction and stroke, both overall and for men and women separately. METHODS: We assessed the association between total and leisure time physical activity on the risk of myocardial infarction and stroke in a cohort of 31,580 men and women through record linkages from 1997-2016. We used Cox proportional hazards regression models to estimate hazard ratios (HR) with 95% confidence intervals (CI) based on detailed self-reported physical activity. In the adjusted analyses, we included age, sex, body mass index, level of education, cigarette smoking, alcohol consumption, diabetes, lipid disturbance and hypertension as potential confounders. RESULTS: We identified 1,621 incident cases of myocardial infarction and 1,879 of stroke. Among men, there was an inverse association between leisure time activity and myocardial infarction in the third tertile compared to the first (HR: 0.78; 95% CI: 0.62-0.98; p for trend = 0.03). We also found an inverse association between leisure time activity and stroke in the third tertile compared to the first (HR: 0.78; 95% CI: 0.61-0.99; p for trend = 0.04), while the corresponding HR for stroke among women was 0.91; 95% CI: 0.74-1.13. We found no significant association between total physical activity and MI (HR: 1.12; 95% CI: 0.93-1.34) or stroke (HR: 1.14 95% CI: 0.94-1.39) comparing the highest to the lowest tertile in men. Women in the highest tertile of total physical activity had a 22% lower risk of myocardial infarction compared to the lowest tertile (HR: 0.78; 95% CI: 0.63-0.97; p for trend = 0.02) and an 8% (95% CI: 0.87-0.98) reduced risk of myocardial infarction with each 1 METh/day increase of leisure time physical activity. CONCLUSION: Total physical activity was inversely associated with the risk of myocardial infarction in women, while leisure time physical activity was inversely associated with the risk of myocardial infarction and stroke in men.
Hummel et al. (2022) conducted a cohort in Myocardial infarction and stroke (n=31,580). Leisure time physical activity vs. Lowest tertile was evaluated on Incident myocardial infarction (HR 0.79, 95% CI 0.66-0.94, p=<0.01). Leisure time physical activity in the highest tertile reduced the risk of myocardial infarction by 21% compared to the lowest tertile among all participants.
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