Release of prostaglandin E2 and unidentified factors from ventilated lungs

Key Points

• The study aims to investigate the release of prostaglandin E2 and unidentified factors from ventilated lungs and their potential impact on blood pressure.
• Isolated guinea-pig lungs were inflated to measure the release of prostaglandin E2 and other substances.
• Observations were made regarding the effects of positive-pressure ventilation on blood pressure.
• Prostaglandin E2 and unidentified substances were significantly released in response to lung inflation.
• The release may be linked to hypotension associated with positive-pressure ventilation.