Randomized trial observes prostaglandin E2 release affecting blood pressure during ventilation, suggesting clinical relevance.
Prostaglandin E2 and unidentified substances were released from isolated lungs of guinea-pigs in response to inflation. If a similar release of prostaglandin occurs in vivo it may contribute to the hypotension which sometimes accompanies positive-pressure ventilation. It is even possible that the phenomenon plays a part in the normal control of blood-pressure.
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Berry et al. (1971) studied this question.
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