Cholecalciferol supplementation of 2000 IU/day for 3 months decreased the prevalence of endothelium-dependent vasodilation impairments in early postmenopausal women (14.3% vs 35.5%, p=0.05).
Cohort (n=102)
Does cholecalciferol supplementation improve endothelial function in women with arterial hypertension and vitamin D deficiency?
Supplementation with cholecalciferol 2000 IU/day for 3 months improves endothelial function in women with arterial hypertension and vitamin D deficiency, particularly in the early postmenopausal period.
Absolute Event Rate: 14.3% vs 35.5%
p-value: p=0.05
Objective: Aim: To assess effect of cholecalciferol on endothelial function in women with arterial hypertension (AH) in premenopausal and early postmenopausal periods who received 25(OH)D supplementation. Design and method: Materials and methods: We investigated 102 women with AH stage II risk 3 aged 5048;53 years: 50 females in premenopausal period – group I and 52 females in early postmenopausal period – group II. Serum level of 25(OH)D was determined by the immunoenzymatic assay. In groups I and II we identified subgroups with the level of 25(OH)D0,05) by EDV. Following the therapy EDV increased (p<0,01) in all groups. Moreover, in subgroup IIB EDV increased (p=0,04) as compared with subgroup IIA, while the prevalence of EDV impairments decreased (p=0,05) (14,3% vs 35,5%, correspondingly). Conclusions: Conclusion: Correction of 25 (OH)D level by intake of cholecalciferol 2000 IU/day for 3 months improves endothelial function in women with AH.
Л В Кежун (Fri,) conducted a cohort in Arterial hypertension (n=102). Cholecalciferol vs. No cholecalciferol was evaluated on Prevalence of endothelium-dependent vasodilation (EDV) impairments in early postmenopausal women (p=0.05). Cholecalciferol supplementation of 2000 IU/day for 3 months decreased the prevalence of endothelium-dependent vasodilation impairments in early postmenopausal women (14.3% vs 35.5%, p=0.05).