Wistar rats are a more suitable normotensive control for Spontaneously Hypertensive Rats than Wistar Kyoto rats, as WKY rats exhibit early reductions in cardiac function and borderline high blood pressure.
Is the Wistar rat a more suitable normotensive control for Spontaneously Hypertensive Rats (SHR) than the Wistar Kyoto rat?
Wistar rats are a more suitable normotensive control for Spontaneously Hypertensive Rats than Wistar Kyoto rats due to the latter's early cardiac function reduction and borderline high blood pressure.
p-value: p=<0.05
Background: There are divergences in the literature regarding the experimental model (Wistar-WIS or Wistar Kyoto-WKY) to be used as a Spontaneously Hypertensive Rat (SHR) control. The characterization of these models in terms of cardiovascular parameters provides researchers with important tools at the time of selection and application in scientific research. Objective: The aim of this study was to evaluate the use of WIS and WKY as a Spontaneously Hypertensive Rat (SHR) control by assessing the long-term behavior of blood ...
Rezende et al. (Tue,) conducted a other in Hypertension (animal model) (n=24). Wistar (WIS) strain vs. Wistar Kyoto (WKY) strain was evaluated on Blood pressure and cardiac structure and function (p=<0.05). Wistar rats are a more suitable normotensive control for Spontaneously Hypertensive Rats than Wistar Kyoto rats, as WKY rats exhibit early reductions in cardiac function and borderline high blood pressure.
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