Key result
Wistar rats are a more suitable normotensive control for Spontaneously Hypertensive Rats than Wistar Kyoto rats, as WKY rats exhibit early reductions in cardiac function and borderline high blood pressure.
Why the study?
Divergences exist in the literature regarding whether Wistar or Wistar Kyoto rats should be used as a Spontaneously Hypertensive Rat control.
Is the Wistar rat a more suitable normotensive control for Spontaneously Hypertensive Rats (SHR) than the Wistar Kyoto rat?
Is the Wistar rat a more suitable normotensive control for Spontaneously Hypertensive Rats (SHR) than the Wistar Kyoto rat?
p-value: p=<0.05
Wistar rats are a more suitable normotensive control for Spontaneously Hypertensive Rats than Wistar Kyoto rats due to the latter's early cardiac function reduction and borderline high blood pressure.
May favor Wistar over WKY as SHR controls; leaves open optimal comparator standardization in hypertension models.
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Rezende et al. (2021) studied Hypertension (animal model) (n=24). Wistar (WIS) strain vs. Wistar Kyoto (WKY) strain was evaluated on Blood pressure and cardiac structure and function (p=<0.05). Wistar rats are a more suitable normotensive control for Spontaneously Hypertensive Rats than Wistar Kyoto rats, as WKY rats exhibit early reductions in cardiac function and borderline high blood pressure.
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