Key result
Wistar-Kyoto rats may be unsuitable controls for spontaneously hypertensive rat studies due to genetic variability.
Population
Spontaneously hypertensive rat (SHR) and Wistar-Kyoto (WKY) rat strains
Design
Review
Authors
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Questions reliability of prior SHR-WKY backcross data; leaves open optimal standardized reference strains for hypertension genetics research.
Highlights genetic variability in SHR and WKY rat colonies worldwide, challenging the suitability of WKY rats as controls in hypertension backcross studies.
Louis et al. (1990) conducted a review in Hypertension (animal model). The Wistar-Kyoto rat strain may not be the most suitable control for backcross studies of spontaneously hypertensive rats due to genetic variability and spontaneous hypertension incidence.
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