October 1, 1998HypertensionOpen Access

Isolation of a Chromosome 1 Region That Contributes to High Blood Pressure and Salt Sensitivity

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Population

Male Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR)

Comparison

Creation of a congenic strain by replacing a… vs Male progenitor WKY rats

Design

Preclinical

Authors

NINaoharu IwaiBroad Institute YTYasuyuki TsujitaShiga University of Medical Science MKMasahiko KinoshitaGoethe University Frankfurt

Discussion

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Implication

Establishes a congenic rat model for salt-sensitive hypertension; leaves open translation to human disease.

Structured PICO

Population

Male Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR)

Intervention

Creation of a congenic strain (WKY.SHR-D1Mit3/Rat57) by replacing a region of chromosome 1 in WKY with the corresponding segment from SHR, with and without salt loading

Comparator

Male progenitor WKY rats

Outcome

Mean blood pressure in the daytime and nighttime assessed by radiotelemetrysurrogate

The study confirms the existence of a gene on rat chromosome 1 that contributes to high blood pressure and salt sensitivity, establishing a new congenic animal model for further mapping.

Cite This Study

Iwai et al. (1998) studied this question.

synapsesocial.com/papers/6a82d3ea3e02825336d11dc5 https://doi.org/10.1161/01.hyp.32.4.636

Topics

Hypertension management

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Isolation of a Chromosome 1 Region That Contributes to High Blood Pressure and Salt Sensitivity

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Isolation of a Chromosome 1 Region That Contributes to High Blood Pressure and Salt Sensitivity

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider