January 1, 2000HypertensionOpen Access

Genetic Analysis of Rat Chromosome 1 and the Sa Gene in Spontaneous Hypertension

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Population

Spontaneously hypertensive rat (SHR) congenic strains

Comparison

Transfer of a subregion of chromosome 1 from the… vs Transfer of a larger region of chromosome 1 that…

Design

Preclinical

Authors

ELElizabeth St. LezinUniversity of California, San Francisco WLWeizhong LiuXinjiang Agricultural University JWJiaming WangBeijing University of Chinese Medicine

Discussion

Member takes

Implication

Excludes Sa gene as mediator of chromosome 1 BP effect in SHR rats; leaves open causal variant identification and human relevance.

Structured PICO

Population

Spontaneously hypertensive rat (SHR) congenic strains

Intervention

Transfer of a subregion of chromosome 1 from the normotensive Brown Norway (BN) rat onto the SHR background that does not include the Sa gene

Comparator

Transfer of a larger region of chromosome 1 that included the Sa gene

Outcome

Blood pressuresurrogate

Molecular variation in the Sa gene is not required for the blood pressure-lowering effect of the chromosome 1 region in the SHR-BN model of hypertension.

Cite This Study

Lezin et al. (2000) studied this question.

synapsesocial.com/papers/6a880170a95381ace1bbf214 https://doi.org/10.1161/01.hyp.35.1.225

Topics

Hypertension management

View Full Paper

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Genetic Analysis of Rat Chromosome 1 and the Sa Gene in Spontaneous Hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Genetic Analysis of Rat Chromosome 1 and the Sa Gene in Spontaneous Hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider