Why the study?
Does a specific region on chromosome 1q affect susceptibility to hypertension-induced renal damage in spontaneously hypertensive rats?
Population
Spontaneously hypertensive rat (SHR) progenitor strain and an SHR congenic strain (SHR.BN-D1Mit3/Igf2)
Comparison
SHR congenic strain carrying a 22 cM segment of… vs SHR progenitor strain subjected to DOCA-salt…
Design
Preclinical
Authors
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Chromosome 1q locus modulates renal injury susceptibility in hypertensive rats; hypothesis-generating for human genetic studies in hypertensive nephropathy.
Does a specific region on chromosome 1q affect susceptibility to hypertension-induced renal damage in spontaneously hypertensive rats?
A specific region on chromosome 1q contains genes that significantly influence susceptibility to hypertension-induced renal damage in the spontaneously hypertensive rat model.
Lezin et al. (1999) studied this question.
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