Population
Male rats from five congenic strains for blood pressure quantitative trait loci on chromosome 1, 12 weeks old
Comparison
Salt-loading using 1% NaCl in drinking water vs Comparison among five congenic strains with…
Design
Preclinical
Follow-up
2 to 5 weeks
Authors
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No immediate implications for hypertension management; leaves open BP-independent genetic mechanisms for salt-induced renal injury in models.
In a rat model, genetic loci on chromosome 1 contribute to salt-induced renal damage independently of basal blood pressure, whereas stroke incidence is strongly correlated with blood pressure.
Ishikawa et al. (2008) studied this question.
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