January 1, 1993Journal of Hypertension

Molecular genetics of the SA-gene: cosegregation with hypertension and mapping to rat chromosome 1

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Population

F2 intercross between stroke-prone spontaneously hypertensive rats (SHRSP) and Wistar-Kyoto (WKY) rats

Comparison

Zygosity at the SA locus (SA-gene genotype) vs Different zygosity at the SA locus

Design

Preclinical

Authors

KLKlaus LindpaintnerBruker (United States)PHPascale HilbertAblynx (Belgium)DGDetlev GantenGeneral / Preventive / Lipids

Discussion

Member takes

Implication

Supports SA locus as candidate in rat salt-sensitive hypertension models; leaves open human relevance and should not change practice.

Structured PICO

Population

F2 intercross between stroke-prone spontaneously hypertensive rats (SHRSP) and Wistar-Kyoto (WKY) rats

Intervention

Zygosity at the SA locus (SA-gene genotype)

Comparator

Different zygosity at the SA locus

Outcome

Systolic and diastolic blood pressure under basal conditions and after sodium loadingsurrogate

The SA-gene on rat chromosome 1 cosegregates with sodium-induced systolic blood pressure increases, supporting its potential role in hypertension pathogenesis.

Cite This Study

Lindpaintner et al. (1993) studied this question.

synapsesocial.com/papers/6a7d51baf1daba58ecd5b500 https://doi.org/10.1097/00004872-199301000-00004

Topics

Hypertension management

View Full Paper

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Molecular genetics of the SA-gene: cosegregation with hypertension and mapping to rat chromosome 1

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Molecular genetics of the SA-gene: cosegregation with hypertension and mapping to rat chromosome 1

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider