What question did this study set out to answer?

Determine whether the SA gene, a candidate locus strongly linked to high blood pressure in genetically hypertensive rats, plays a role in human essential hypertension.

January 1, 1995Hypertension

Evaluation of the SA Locus in Human Hypertension

View Full Paper

Ask AI

Bookmark

Why the study?

Is the SA gene locus associated with human hypertension?

Population

A large sample of hypertensive patients, normotensive control subjects, and multiplex sibships.

Comparison

Genetic association and linkage analysis of the… vs Normotensive control subjects.

Design

Other

Authors

TNToru NabikaShimane University ABAlain BonnardeauxMedical Council of Canada MJMichael R. JamesUniversity of North Carolina at Charlotte

Discussion

Member takes

Implication

SA gene locus not implicated in human hypertension; challenges rodent model translation and leaves alternative loci open.

Key Points

Determine whether the SA gene, a candidate locus strongly linked to high blood pressure in genetically hypertensive rats, plays a role in human essential hypertension.
Cloned human SA cDNA from a liver library and mapped the gene to human chromosome 16p13.11-12.3 using a yeast artificial chromosome-derived microsatellite marker.
Identified intron polymorphisms and performed genetic linkage and association studies in a large cohort of hypertensive patients, normotensive controls, and multiplex sibships.
Identified two introns within the human SA gene, including a frequent single nucleotide substitution (cytosine to thymidine at residue 79 of the intron).
Observed no evidence of genetic linkage or association between the SA locus or adjacent microsatellite markers and hypertension in human subjects.

Structured PICO

Is the SA gene locus associated with human hypertension?

Population

A large sample of hypertensive patients, normotensive control subjects, and multiplex sibships.

Intervention

Genetic association and linkage analysis of the SA locus.

Comparator

Normotensive control subjects.

Outcome

Association and linkage of the SA gene with human hypertension.surrogate

Despite its role in rat models of hypertension, the SA gene locus does not appear to be associated with human hypertension.

Cite This Study

Nabika et al. (1995) studied this question.

synapsesocial.com/papers/6a8a65cd754a5a619a723a5f https://doi.org/10.1161/01.hyp.25.1.6

Topics

Hypertension management

View Full Paper

Ask AI

Bookmark

Evaluation of the SA Locus in Human Hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Evaluation of the SA Locus in Human Hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider